Journal: Oncology Reports
Article Title: Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice
doi: 10.3892/or.2023.8583
Figure Lengend Snippet: Toxicity profiles of PADI2 inhibitor. Evaluation of histology and function of retina after intravitreal injection of PBS and 2 µM BB-Cl-amidine in mice. (A) Visual acuity was evaluated through optomotor response in different groups. (B) The a-wave (left) and b-wave (right) were measured by electroretinography in different groups. (C and D) (C) Representative images (magnification, ×200) and (D) quantitative analyses of hematoxylin and eosin staining of various groups. (E and F) (E) Representative images (magnification, ×200) and (F) quantitative analyses of TUNEL assay. The number of apoptotic cells did not show a statistically significant difference between the groups. (G) Schematic of summary. Scale bar, 50 µm (n=3). Bars represent SEM. NS, not significant, as determined by unpaired Student's t-test.
Article Snippet: Optomotor response measurement (OptoMotry HD; CerebralMechanics) and electroretinography (cat. no. UTAS E-2000; LKC Technologies) were performed 1 week after injection according to previous guidelines ( ).
Techniques: Drug discovery, Injection, Staining, TUNEL Assay